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Chemical Structure : Ro 67-7476
CAS No.: 298690-60-5
Catalog No.: PC-42135Not For Human Use, Lab Use Only.
A potent, selective positive allosteric modulator (potentiator) of rat mGlu1R with pEC50 of 6.76 for the potentiation of 3 uM glutamate-induced Ca2+ int currents.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $128 | In stock | |
| 50 mg | $528 | In stock | |
| 100 mg | $880 | In stock |
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A potent, selective positive allosteric modulator (potentiator) of rat mGlu1R with pEC50 of 6.76 for the potentiation of 3 uM glutamate-induced Ca2+ int currents; has no activity for mGluR5 at 1 uM and Adrenergic α1, α2, β1, β2 and GABAA at 10 uM; has no effect on the glutamate-induced currents in human mGlu1a receptor-expressing cells.
| M.Wt | 319.3937 | |
| Formula | C17H18FNO2S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 40 mg/mL |
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| Chemical Name/SMILES |
Pyrrolidine, 2-(4-fluorophenyl)-1-[(4-methylphenyl)sulfonyl]-, (2S)- |
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1. Hemstapat K, et al. Mol Pharmacol. 2006 Aug;70(2):616-26.
2. Knoflach F, et al. Proc Natl Acad Sci U S A. 2001 Nov 6;98(23):13402-7.
3. Sheffler DJ, et al. Neuropharmacology. 2008 Sep;55(4):419-27.
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