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Chemical Structure : Rolipram
CAS No.: 61413-54-5
Catalog No.: PC-45080Not For Human Use, Lab Use Only.
A potent, selective inhibitor of phosphodiesterases PDE4 with IC50 of 3 nM, 130 nM and 240 nM for PDE4A, PDE4B, and PDE4D, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 50 mg | $52.8 | In stock | |
| 100 mg | $78.4 | In stock |
Bulk size, bulk discount!
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A potent, selective inhibitor of phosphodiesterases PDE4 with IC50 of 3 nM, 130 nM and 240 nM for PDE4A, PDE4B, and PDE4D, respectively; increases phosphorylation of CREB in U937 cells in a dose-dependent fashion, dose-dependently inhibits the IFN-gamma-stimulated phosphorylation of p38 MAPK with IC50 of 290 nM; inhibits TNF production, attenuates carrageenan-induced paw inflammation in mice.
Asthma
Phase 2 Clinical
| M.Wt | 275.3428 | |
| Formula | C16H21NO3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 41 mg/mL |
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| Chemical Name/SMILES |
2-Pyrrolidinone, 4-[3-(cyclopentyloxy)-4-methoxyphenyl]- |
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1. MacKenzie SJ, et al. Biochem J. 2000 Apr 15;347(Pt 2):571-8.
2. Korhonen R, et al. Br J Pharmacol. 2013 Aug;169(7):1525-36.
3. Shalaby AM, et al. J Pharmacol Pharmacother. 2012 Apr;3(2):132-7.
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