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Chemical Structure : Romidepsin
CAS No.: 128517-07-7
Catalog No.: PC-20784Not For Human Use, Lab Use Only.
Romidepsin (FK228, NSC 63017, R 901228, Depsipeptide) is a natrual produrct from Chromobacterium violaceum as class I HDACs inhibitor, inhibits HDAC1, HDAC2, HDAC4, and HDAC6 with IC50s of 36 nM, 47 nM, 510 nM and 1400 nM, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $248 | In stock | |
| 10 mg | $398 | In stock | |
| 25 mg | Get quote | ||
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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Romidepsin (FK228, NSC 63017, R 901228, Depsipeptide) is a natrual produrct from Chromobacterium violaceum as class I HDACs inhibitor, inhibits HDAC1, HDAC2, HDAC4, and HDAC6 with IC50s of 36 nM, 47 nM, 510 nM and 1400 nM, respectively.
Romidepsin (FK228) has demonstrated potent in vitro and in vivo cytotoxic activity against murine and human tumor cell lines.
Romidepsin (FK228) strongly inhibited the growth of U-937 cells with IC50 of 5.92 nM.
Romidepsin (FK228) prolonged the survival time of scid mice in a lymphoma model.
Romidepsin (FK228) showed beneficial effects of FK228 on human lymphoma may be exerted through the induction of apoptosis, cell cycle arrest, and differentiation via the modulation of gene expression by histone acetylation.
| M.Wt | 540.69 | |
| Formula | C24H36N4O6S2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(1S,4S,7Z,10S,16E,21R)-7-Ethylidene-4,21-diisopropyl-2-oxa-12,13-dithia-5,8,20,23-tetraazabicyclo[8.7.6]tricos-16-ene-3,6,9,19,22-pentaone |
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1. Ueda H, et al. J Antibiot (Tokyo). 1994 Mar;47(3):301-10.
2. Furumai R, et al. Cancer Res. 2002 Sep 1;62(17):4916-21.
3. Piekarz RL, et al. Blood. 2001 Nov 1;98(9):2865-8.
4. Sasakawa Y, et al. Biochem Pharmacol. 2002 Oct 1;64(7):1079-90.
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