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Chemical Structure : Roniciclib
CAS No.: 1223498-69-8
Catalog No.: PC-61246Not For Human Use, Lab Use Only.
Roniciclib (BAY 1000394) is a potent, orally active, pan-CDK inhibitor with IC50 of 7/9/11 nM for CDK1/2/4 respectively, inhibits transcriptional CDK9/7 with IC50 of 5-25 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $298 | In stock | |
| 10 mg | $458 | In stock | |
| 25 mg | $798 | In stock | |
| 100 mg | Get quote |
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Roniciclib (BAY 1000394) is a potent, orally active, pan-CDK inhibitor with IC50 of 7/9/11 nM for CDK1/2/4 respectively, inhibits transcriptional CDK9/7 with IC50 of 5-25 nM.
BAY1000394 inhibits 16 additional kinase in a panel of 214 non-CDK Ser/Thr and Tyr kinases.
BAY1000394 simultaneously inhibits cell-cycle progression and RNA polymerase II-mediated gene transcription, shows broad and uniform inhibitory activity on cell proliferation with IC50 of 8-33 nM.
BAY1000394 potently inhibits growth of various human tumor xenografts.
| M.Wt | 430.44 | |
| Formula | C18H21F3N4O3S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(R)-S-Cyclopropyl-S-(4-{[4-{[(1R,2R)-2-hydroxy-1-methylpropyl]oxy}-5-(trifluoromethyl)pyrimidin-2-yl]amino}phenyl)sulfoximide |
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1. Siemeister G, et al. Mol Cancer Ther. 2012 Oct;11(10):2265-73.
2. Lücking U, et al. ChemMedChem. 2013 Jul;8(7):1067-85.
3. Ayaz P, et al. ACS Chem Biol. 2016 Jun 17;11(6):1710-9.
4. Bahleda R, et al. Br J Cancer. 2017 Jun 6;116(12):1505-1512.
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