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Chemical Structure : Rozanolixizumab
CAS No.:
Catalog No.: PC-Ab1091Not For Human Use, Lab Use Only.
Rozanolixizumab (UCB7665) is a humanised, high-affinity, human IgG4 anti-FcRn monoclonal antibody, binds to human FcRn and cynomolgus monkey FcRn with a similar affinity at both pH 6.0 (Kd=23 pM and 25 pM, human and cynomolgus monkey, respectively) and pH 7.4 (34 pM and 53 pM, human and cynomolgus monkey, respectively. Rozanolixizumab inhibits the recycling (IC50=0.41 nM) of human IgG by human FcRn-transfected MDCK cells in a dose-dependent manner. The neonatal Fc receptor (also FcRn, IgG recept
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Rozanolixizumab (UCB7665) is a humanised, high-affinity, human IgG4 anti-FcRn monoclonal antibody, binds to human FcRn and cynomolgus monkey FcRn with a similar affinity at both pH 6.0 (Kd=23 pM and 25 pM, human and cynomolgus monkey, respectively) and pH 7.4 (34 pM and 53 pM, human and cynomolgus monkey, respectively. Rozanolixizumab inhibits the recycling (IC50=0.41 nM) of human IgG by human FcRn-transfected MDCK cells in a dose-dependent manner. The neonatal Fc receptor (also FcRn, IgG receptor FcRn large subunit p51, or Brambell receptor) is a protein that in humans is encoded by the FCGRT gene. It is an Fc receptor which is similar in structure to the MHC class I moleculethat functions to protect IgG and albumin from catabolism, mediates transport of IgG across epithelial cells, and is involved in antigen presentation by professional antigen presenting cells.
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| Formula | Human IgG4-Lambda2 | |
| Appearance | Solid | |
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| Solubility |
PBS, pH 7.0 Contains no stabilizers or preservatives |
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