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Chemical Structure : Rucaparib
CAS No.: 283173-50-2
Catalog No.: PC-42680Not For Human Use, Lab Use Only.
Rucaparib (AG014699, PF01367338) is a potent inhibitor of PARP with Ki of 1.4 nM for PARP1 in a cell-free assay, also showing binding affinity to eight other PARP domains.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $118 | In stock | |
| 25 mg | $188 | In stock | |
| 50 mg | $298 | In stock | |
| 100 mg | $458 | In stock | |
| 250 mg | Get quote |
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Rucaparib (AG014699, PF01367338) is a potent inhibitor of PARP with Ki of 1.4 nM for PARP1 in a cell-free assay, also showing binding affinity to eight other PARP domains.
Rucaparib (AG014699, PF01367338) inhibits PARP-1 activity by 97.1% at a concentration of 1 μM in permeabilised D283Med cells.
Rucaparib (AG014699, PF01367338) enhances the antitumor activity of temozolomide and indicates complete and sustained tumor regression in NB1691 and SHSY5Y xenografts.
| M.Wt | 323.3641 | |
| Formula | C19H18FN3O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
6H-Pyrrolo[4,3,2-ef][2]benzazepin-6-one, 8-fluoro-1,3,4,5-tetrahydro-2-[4-[(methylamino)methyl]phenyl]- |
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1. Thomas HD, et al. Mol Cancer Ther, 2007, 6(3), 945-956.
2. Daniel RA, et al. Clin Cancer Res, 2009, 15(4), 1241-1249.
3. Daniel RA, et al. Br J Cancer, 2010, 103(10), 1588-1596.
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