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Chemical Structure : Rv1625c agonist V-59
Catalog No.: PC-72873Not For Human Use, Lab Use Only.
Rv1625c agonist V-59 (V-59) is a specific small molecule agonist of the Mtb adenylyl cyclase Rv1625c, inhibits Mtb growth in macrophages (EC50=0.3 uM) in an Rv1625c-dependent mechanism.
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Rv1625c agonist V-59 (V-59) is a specific small molecule agonist of the Mtb adenylyl cyclase Rv1625c, inhibits Mtb growth in macrophages (EC50=0.3 uM) in an Rv1625c-dependent mechanism.
V-59 inhibits Mtb growth in cholesterol media (EC50 0.70 uM), but not in media containing the two-carbon fatty acid acetate, or in standard rich growth media.
V-59 stimulates Rv1625c to produce cAMP, which is necessary for V-59 to inhibit Mtb growth.
Chemically activating Rv1625c via V-59 preferentially inhibits cholesterol utilization in WT Mtb, rather than equally inhibiting all lipid utilization by the bacterium.
| M.Wt | 371.376 | |
| Formula | C17H18FN7O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Kaley M Wilburn, et al. PLoS Pathog. 2022 Feb 8;18(2):e1009862.
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