Chemical Structure : S-570
CAS No.:
2718206-92-7
S-570
(S570)
Catalog No.: PC-27724Not For Human Use, Lab Use Only.
S-570 is a potent, covalent, orally available STING antagonist with IC50 of 41 nM (hSTING), covalently binds to Cys91, inhibits IFN-β secretion in 2′,3′-cGAMP-stimulated THP-1 cells with IC50 of 18 nM.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
S-570 is a potent, covalent, orally available STING antagonist with IC50 of 41 nM (hSTING), covalently binds to Cys91, inhibits IFN-β secretion in 2′,3′-cGAMP-stimulated THP-1 cells with IC50 of 18 nM.
S-570 selectively inhibits STING signaling while showing only minimal activity against RIG-I- or TLR4-mediated innate immune signaling pathways.
S-570 also exhibits potent antagonist activity against mouse STING with IC50 of 71 nM in cell-based reporter assay using B16 cells stimulated with the STING agonist CMA (10-carboxymethyl-9-acridanone).
S-570 significantly suppressed plasma levels of IFN-β, IL-6 and TNF-α stimulated by CMA in mice.
S-570 effectively attenuated systemic inflammation in a CMA-stimulated mouse model.
Physicochemical Properties
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M.Wt
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364.76
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Formula
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C17H12ClF3N4
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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N-(5-chloro-1H-indol-3-yl)-1-methyl-5-(trifluoromethyl)-1H-benzo[d]imidazol-2-amine
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References
1. Kiyoi T, et al. Bioorg Med Chem Lett. 2026 Aug 6;141:130757.
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