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Chemical Structure : S-777469
Catalog No.: PC-49218Not For Human Use, Lab Use Only.
S-777469 (S777469) is a potent, selective, orally available cannabinoid receptor 2 (CB2) receptor agonist with Ki value of 32 nM (hCB2), >100-fold selectivity over CB1.
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S-777469 (S777469) is a potent, selective, orally available cannabinoid receptor 2 (CB2) receptor agonist with Ki value of 32 nM (hCB2), >100-fold selectivity over CB1.
S-777469 significantly suppressed scratching behavior induced by histamine or substance P in mice or by serotonin in rats.
S-777469 significantly suppressed DNFB-induced ear swelling in a dose-dependent manner.
S-777469 significantly alleviated mite antigen-induced atopic dermatitis-like skin lesions in NC/Nga mice.
| M.Wt | 414.477 | |
| Formula | C23H27FN2O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Odan M, et al. Bioorg Med Chem Lett. 2012 Apr 15;22(8):2803-6.
2. Sekiguchi K, et al. Xenobiotica. 2014 Jan;44(1):48-58.
3. Haruna T, et al. Pharmacology. 2015;95(1-2):95-103.
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