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Chemical Structure : S107
CAS No.: 927871-76-9
Catalog No.: PC-21371Not For Human Use, Lab Use Only.
S107 (RyR2 stabilizer) is a specific stabilizing cmpound of Ca2+ release channel ryanodine receptor 2 (RyR2), enhances calstabin2 binding and inhibits Ca2+ leak from mutant RyR2 channels.
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|---|---|---|---|
| 5 mg | $128 | In stock | |
| 10 mg | $188 | In stock | |
| 25 mg | $298 | In stock | |
| 100 mg | Get quote |
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S107 (RyR2 stabilizer) is a specific stabilizing cmpound of Ca2+ release channel ryanodine receptor 2 (RyR2), enhances calstabin2 binding and inhibits Ca2+ leak from mutant RyR2 channels.
S107 does not interact with over 400 receptors, enzymes, and ion channels in screens using up to 10 μM.
S107 also shows no effect on cardiac ion channels including the voltage-gated Na+, K+, and Ca2+ channels at concentrations up to 10 μM, and no effect on normal Ca2+ signaling in cells.
S107 prevents depletion of calstabin1 from the RyR1 complex improved force generation and exercise capacity, reduced Ca2+-dependent neutral protease calpain activity and plasma creatine kinase levels.
S107 improves Ca2+ handling in muscle fibers and reduces muscle fatigue.
| M.Wt | 209.31 | |
| Formula | C11H15NOS | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
2,3,4,5-Tetrahydro-7-methoxy-4-methyl-1,4-benzothiazepine |
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1. Lehnart SE, et al. J Clin Invest. 2008 Jun;118(6):2230-45.
2. Bellinger A.M., et al. Proc. Natl. Acad. Sci. U. S. A. 2008;105:2198–2202.
3. Wehrens XH, et al. Science. 2004;304:292–296.
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