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S118

Chemical Structure : S118

CAS No.: 2677041-36-8

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S118 (S-118, S1P2 receptor antagonist)

Catalog No.: PC-27966Not For Human Use, Lab Use Only.

S118 is a potent, selective antagonist of sphingosine-1-phosphate receptor 2 (S1P2 receptor), attenuates idiopathic pulmonary fibrosis (IPF) through anti-inflammatory, anti-fibrosis, and anti-EMT effects.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

S118 is a potent, selective antagonist of sphingosine-1-phosphate receptor 2 (S1P2 receptor), attenuates idiopathic pulmonary fibrosis (IPF) through anti-inflammatory, anti-fibrosis, and anti-EMT effects.

Physicochemical Properties

M.Wt 446.27
Formula C19H14Cl2FN7O
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N-(2,6-dichloropyridin-4-yl)-2-(4-(4-fluorophenyl)-1-methyl-1H-pyrazolo[3,4-b]pyridin-6-yl)hydrazine-1-carboxamide

References

1. Mu SY, et al. Br J Pharmacol. 2026 Feb;183(4):957-972.

2. Shao HB, et al. Br J Pharmacol. 2026 Oct;183(19):5854-5870.

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