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S130

Chemical Structure : S130

CAS No.: 1160852-22-1

S130 (ATG4B inhibitor S130)

Catalog No.: PC-35632Not For Human Use, Lab Use Only.

S130 (ATG4B inhibitor S130) is a potent, specific ATG4B inhibitor with IC50 of 3.24 uM, shows strong affinity (Kd=4 uM) and specifically suppresses the activity of ATG4B, but not other proteases.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

S130 (ATG4B inhibitor S130) is a potent, specific ATG4B inhibitor with IC50 of 3.24 uM, shows strong affinity (Kd=4 uM) and specifically suppresses the activity of ATG4B, but not other proteases.
S130 displays no inhibitory effects on cysteine proteases such as CASP3 (caspase 3), CASP8 (caspase 8) and CASP9 (caspase 9), or aspartic proteases.
S130 does not cause the impairment of autophagosome fusion, nor does it result in the dysfunction of lysosomes.
S130 causes cell death of colorectal cancer cells in vitro and in vivo.

Physicochemical Properties

M.Wt 387.483
Formula C24H25N3O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

N-(3-(diethylamino)propyl)-7-oxo-7H-dibenzo[de,g]quinoline-4-carboxamide

References

1. Fu Y, et al. Autophagy. 2018 Sep 3. doi: 10.1080/15548627.2018.1517073.

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