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Chemical Structure : S18-000003
CAS No.: 2068119-11-7
Catalog No.: PC-35828Not For Human Use, Lab Use Only.
S18-000003 (S18-000003) is a potent, selective, orally bioavailable RORγt inhibitor with IC50 of 29 nM (hRORγt, GAL4), shows no significant activity against RORα, RORβ and LXRα/β(IC50>10 uM).
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $228 | In stock | |
| 10 mg | $358 | In stock | |
| 25 mg | $558 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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S18-000003 (S18-000003) is a potent, selective, orally bioavailable RORγt inhibitor with IC50 of 29 nM (hRORγt, GAL4), shows no significant activity against RORα, RORβ and LXRα/β(IC50>10 uM).
S18-000003 inhibits IL-17 production in the skin of IL-23-treated mice by oral administration (30 mg/kg).
| M.Wt | 518.551 | |
| Formula | C26H25F3N2O4S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
N-(2,4-difluorophenyl)-2-(4-(2-(4-(ethylsulfonyl)phenyl)acetamido)-2-fluorophenyl)-2-methylpropanamide |
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1. Sasaki Y, et al. Bioorg Med Chem Lett. 2018 Dec 1;28(22):3549-3553.
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