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Chemical Structure : S1RA
CAS No.: 878141-96-9
Catalog No.: PC-45417Not For Human Use, Lab Use Only.
S1RA (E52862) is a potent and selective sigma-1 receptor (S1R) antagonist with Ki of 17 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $198 | In stock | |
| 25 mg | $328 | In stock | |
| 50 mg | $528 | In stock | |
| 100 mg | Get quote |
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S1RA (E52862) is a potent and selective sigma-1 receptor (S1R) antagonist with Ki of 17 nM.
S1RA (E52862) shows excellent selectivity over sigma-2 receptor (Ki>1 uM).
S1RA (E52862) shows high activity in the mouse capsaicin model of neurogenic pain, exerts dose-dependent antinociceptive effects in several neuropathic pain models.
| M.Wt | 337.4155 | |
| Formula | C20H23N3O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
Morpholine, 4-[2-[[5-methyl-1-(2-naphthalenyl)-1H-pyrazol-3-yl]oxy]ethyl]- |
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1. Díaz JL, et al. J Med Chem. 2012 Oct 11;55(19):8211-24.
2. Romero L, et al. Br J Pharmacol. 2012 Aug;166(8):2289-306.
3. Nieto FR, et al. J Pain. 2012 Nov;13(11):1107-21.
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