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Chemical Structure : S3I-1757
Catalog No.: PC-20628Not For Human Use, Lab Use Only.
S3I-1757 is a small molecule STAT3-STAT3 dimerization inhibitor with IC50 of 13.5 uM in fluorescence polarization (FP) assays, interacts with Y-705 binding site in the SH2 domain.
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S3I-1757 is a small molecule STAT3-STAT3 dimerization inhibitor with IC50 of 13.5 uM in fluorescence polarization (FP) assays, interacts with Y-705 binding site in the SH2 domain.
S3I-1757 disrupts intracellular STAT3-STAT3 dimerization and STAT3-EGFR binding in intact cells.
S3I-1757 (50-200 uM) decreases phosphotyrosine STAT3 levels in the nucleus of human MDA-MB-468 breast cancer cells, inhibits STAT3-DNA binding.
S3I-1757 (50-200 uM, 18h) inhibits STAT3-dependent transcriptional activity and decreases the expression of STAT3-regulated genes in MDA-MB-468 cells.
S3I-1757 inhibits anchorage-dependent proliferation selectively, and inhibits migration and invasion selectively in human cancers that harbor high levels of P-STAT3.
| M.Wt | 521.61 | |
| Formula | C33H31NO5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Zhang X, et al. Cancer Res. 2013 Mar 15;73(6):1922-33.
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