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S6821

Chemical Structure : S6821

CAS No.: 1119831-25-2

S6821 (S 6821, S-6821)

Catalog No.: PC-72152Not For Human Use, Lab Use Only.

S6821 (S 6821) is a potent and selective bitter taste receptor TAS2R8 with IC50 of 21 nM.

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    Biological Activity

    S6821 (S 6821) is a potent and selective bitter taste receptor TAS2R8 antagonist with IC50 of 21 nM.
    S6821 shows high selectivity against a panel of 16 TAS2Rs, effectively attenuates the bitterness of coffee, and displays very good safety profiles.

    Physicochemical Properties

    M.Wt 381.392
    Formula C19H19N5O4
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    3-(1-((3,5-dimethylisoxazol-4-yl)methyl)-1H-pyrazol-4-yl)-1-(3-hydroxybenzyl)imidazolidine-2,4-dione

    References

    1. Fotsing JR, et al. J Med Chem. 2020 May 14;63(9):4957-4977.

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