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Chemical Structure : S6K2 inhibitor Compound 2
Catalog No.: PC-72701Not For Human Use, Lab Use Only.
S6K2 inhibitor Compound 2 is the first potent and highly isoform-specific S6K2 inhibitor with IC50 of 22 nM, inactive for the closely related isoform S6K1 at 5 uM.
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S6K2 inhibitor Compound 2 is the first potent and highly isoform-specific S6K2 inhibitor with IC50 of 22 nM, inactive for the closely related isoform S6K1 at 5 uM.
S6K2 inhibitor Compound 2 did not show significant inhibitory activity against MAPKAPK2, MAPKAPK3, FGFR4, and TTK kinases, except for FGFR4 (IC50=216 nM).
| M.Wt | 561.954 | |
| Formula | C24H23ClF3N9O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Stefan Gerstenecker, et al. Cancers (Basel). 2021 Oct 13;13(20):5133.
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