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Chemical Structure : SAGE-718
Catalog No.: PC-49063Not For Human Use, Lab Use Only.
SAGE-718 is a potent and high intrinsic activity N-Methyl-d-aspartate receptor (NMDAR) positive allosteric modulator with EC50 of 86 and 79 nM for GluN2A and GluN2B, respectively, reverses DOI-induced increases in locomotor activity.
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SAGE-718 is a potent and high intrinsic activity N-Methyl-d-aspartate receptor (NMDAR) positive allosteric modulator with EC50 of 86 and 79 nM for GluN2A and GluN2B, respectively, reverses DOI-induced increases in locomotor activity.
Administration of SAGE-718 (1 mg/kg DOI) significantly increased locomotor activity and rearing compared to vehicle.
Acute administration of SAGE-718 (5-10 mg/kg) significantly reduced DOI-induced increases in distance traveled and rearing during the first 30 min after DOI administration.
SAGE-718 is currently in a placebo-controlled phase 2 clinical study to evaluate its impact on cognitive deficits in an HD patient population.
| M.Wt | 456.634 | |
| Formula | C27H43F3O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Matthew D Hill, et al. J Med Chem. 2022 Jul 2. doi: 10.1021/acs.jmedchem.2c00313.
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