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Chemical Structure : SARS-CoV-2 PLpro inhibitor 7
Catalog No.: PC-49191Not For Human Use, Lab Use Only.
SARS-CoV-2 PLpro inhibitor 7 is a potent, selective and covalent inhibitor of SARS-CoV-2 papain-like protease (PLpro) with IC50 of 94 nM, shows SARS-CoV-2 antiviral activity with EC50 of 1.1 uM.
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SARS-CoV-2 PLpro inhibitor 7 is a potent, selective and covalent inhibitor of SARS-CoV-2 papain-like protease (PLpro) with IC50 of 94 nM, shows SARS-CoV-2 antiviral activity with EC50 of 1.1 uM.
SARS-CoV-2 PLpro inhibitor 7 engages in a hydrogen bond with Trp106 of PLpro.
SARS-CoV-2 PLpro inhibitor 7 inhibits PLpro-mediated peptide cleavage, ubiquitin cleavage, and ISG15 cleavage, has antiviral activity against SARS-CoV-2 and lack cytotoxicity in Vero E6 cells.
SARS-CoV-2 PLpro inhibitor 7 deoes not inhibit a representative panel of human DUBs.
SARS-CoV-2 PLpro inhibitor 7 inhibits PLpro with Ub-rhodamine and ISG15 substrates with IC50 values of 76 and 39 nM, respectively.
| M.Wt | 473.529 | |
| Formula | C27H27N3O5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Sanders B, et al. Res Sq. 2022 Jul 21:rs.3.rs-1840200.
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