Welcome to Shanghai Probechem Biochemicals Co Ltd !Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : SAS-0132
Catalog No.: PC-61100Not For Human Use, Lab Use Only.
SAS-0132 (SAS132) is a novel potent, subtype-selective, brain penetrant sigma 2 receptor/PGRMC1 ligand with Ki of 90 nM, 9-fold selectivity over sigma 1 receptors.
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
SAS-0132 (SAS132) is a novel potent, subtype-selective, brain penetrant sigma 2 receptor/PGRMC1 ligand with Ki of 90 nM, 9-fold selectivity over sigma 1 receptors.
SAS-0132 also exhibits low off-target affinity for most CNS-relevant targets, including opioid, adrenergic, nACR, mAChR, and NMDA receptors.
SAS-0132 modulates intracellular Ca2+ levels in human SK-N-SH neuroblastoma cells, and is neuroprotective in a C. elegans model of amyloid precursor protein-mediated neurodegeneration, improves cognitive performance in transgenic mouse model of AD.
| M.Wt | 391.515 | |
| Formula | C24H29N3O2 | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
1. Yi B, et al. J Neurochem. 2017 Feb;140(4):561-575.
2. Sahn JJ, et al. ACS Chem Neurosci. 2017 Aug 16;8(8):1801-1811.
3. Sahn JJ, et al. ChemMedChem. 2016 Mar 17;11(6):556-61.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
