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Chemical Structure : SB-328437
CAS No.: 247580-43-4
Catalog No.: PC-20723Not For Human Use, Lab Use Only.
SB-328437 is a potent, selective non-peptide CC chemokine receptor-3 (CCR3) antagonist, inhibits 125I-eotaxin binding to human eosinophils with IC50 of 4.5 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $188 | In stock | |
| 25 mg | $298 | In stock | |
| 50 mg | $488 | In stock | |
| 100 mg | Get quote | ||
| 1 g | Get quote |
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SB-328437 is a potent, selective non-peptide CC chemokine receptor-3 (CCR3) antagonist, inhibits 125I-eotaxin binding to human eosinophils with IC50 of 4.5 nM.
SB-328437 inhibits binding of 125I-MCP-4 to human eosinophils with IC50 value of 7 nM.
SB-328437 (30 uM) does not inhibit the binding of 125I-IL-8 to CHO-CXCR1 cell or CHO-CXCR2 cell membranes, 125I-SLC (CCL-21) to HEK-293-CCR7 membranes, or [3H]LTD4 to guinea pig lung membranes.
SB-328437 is 250-fold selective for CCR3 over the other 7-TM receptors tested.
SB-328437 is potent inhibitor of eotaxin- and MCP-4-induced Ca(2+) mobilization in RBL-2H3-CCR3 cells and eosinophils.
| M.Wt | 378.38 | |
| Formula | C21H18N2O5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
O=C(OC)[C@@H](NC(C1=C2C=CC=CC2=CC=C1)=O)CC3=CC=C([N+]([O-])=O)C=C3 |
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1. White JR, et al. J Biol Chem. 2000 Nov 24;275(47):36626-31.
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