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Chemical Structure : SB-366791
CAS No.: 472981-92-3
Catalog No.: PC-42931Not For Human Use, Lab Use Only.
SB-366791 (SB366791) is a potent and selective vanilloid receptor (VR1/TRPV1) antagonist with IC50 of 5.7 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg (Free Sample) | $28 | In stock | |
| 10 mg | $78 | In stock | |
| 25 mg | $138 | In stock | |
| 50 mg | $228 | In stock | |
| 100 mg | Get quote |
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SB-366791 (SB366791) is a potent and selective vanilloid receptor (VR1/TRPV1) antagonist with IC50 of 5.7 nM.
SB-366791 inhibits the response to capsaicin with pK(b) of 7.74 in FLIPR-based Ca(2+)-assay.
SB-366791 shows good selectivity profile exhibiting little or no effect in a panel of 47 binding assays and no effect on either the I(h) or Voltage-gated Ca(2+)-channels in cultured rodent sensory neurones.
| M.Wt | 287.7409 | |
| Formula | C16H14ClNO2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 39 mg/mL |
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| Chemical Name/SMILES |
2-Propenamide, 3-(4-chlorophenyl)-N-(3-methoxyphenyl)- |
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1. Gunthorpe MJ, et al. Neuropharmacology. 2004 Jan;46(1):133-49.
2. Varga A, et al. Neurosci Lett. 2005 Sep 9;385(2):137-42.
3. Lappin SC, et al. Eur J Pharmacol. 2006 Jul 1;540(1-3):73-81.
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