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Chemical Structure : SB-3CT
CAS No.: 292605-14-2
Catalog No.: PC-42999Not For Human Use, Lab Use Only.
SB-3CT is a potent, selective gelatinase inhibitor that dually inhibits MMP2/9 with Ki of 13.9 and 600 nM, display little to no affinity for MMP-3, 7 and 1 (Ki=15, 96 and 206 uM).
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 25 mg | $188 | In stock | |
| 50 mg | $298 | In stock | |
| 100 mg | Get quote |
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SB-3CT is a potent, selective gelatinase inhibitor that dually inhibits MMP2/9 with Ki of 13.9 and 600 nM, display little to no affinity for MMP-3, 7 and 1 (Ki=15, 96 and 206 uM).
SB-3CT also poorly inhibits the closely related zinc-dependent metalloprotease ADAM-17.
SB-3CT demonstrates antitumor activity in a mouse model of T-cell lymphoma and shows significant reduction in the growth and number of experimental liver metastases and to an increase in survival.
SB-3CT blocks MMP-9 activity, including MMP-9-mediated laminin cleavage, thus rescuing neurons from apoptosis in transient focal cerebral ischemia
| M.Wt | 306.3999 | |
| Formula | C15H14O3S2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
Thiirane, 2-[[(4-phenoxyphenyl)sulfonyl]methyl]- |
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1. Krüger A, et al. Cancer Res. 2005 May 1;65(9):3523-6.
2. Brown S, et al. Potent and Selective Mechanism-Based Inhibition of Gelatinases. J. Am. Chem. Soc., 2000, 122 (28), pp 6799-6800.
3. Gu Z, et al. J Neurosci. 2005 Jul 6;25(27):6401-8.
4. Bonfil RD, et al. Int J Cancer. 2006 Jun 1;118(11):2721-6.
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