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Chemical Structure : SB-612111 hydrochloride
Catalog No.: PC-60800Not For Human Use, Lab Use Only.
A potent, selective opiate receptor-like orphan receptor (ORL-1, NOP) antagonist with Ki of 0.33 nM.
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A potent, selective opiate receptor-like orphan receptor (ORL-1, NOP) antagonist with Ki of 0.33 nM; displays good selectivity versus mu-(174-fold), delta-(6391-fold), and kappa (486-fold)-opioid receptors; antagonizes the antimorphine action of nociceptin (ED50= 0.69 mg/kg) with no measurable antinociceptive effects in vivo; antagonizes nociceptin-induced thermal hyperalgesia (ED50=0.62 mg/kg i.v.) in rat carrageenan inflammatory pain model.
| M.Wt | 454.86 | |
| Formula | C24H29Cl2NO.HCl | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Liao YY, et al. Eur J Pharmacol. 2011 Apr 25;657(1-3):84-8.
2. Spagnolo B, et al. J Pharmacol Exp Ther. 2007 Jun;321(3):961-7.
3. Rizzi A, et al. J Pharmacol Exp Ther. 2007 Jun;321(3):968-74.
4. Zaratin PF, et al. J Pharmacol Exp Ther. 2004 Feb;308(2):454-61.
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