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Chemical Structure : SB-705498
CAS No.: 501951-42-4
Catalog No.: PC-42688Not For Human Use, Lab Use Only.
SB-705498 (SB705498) is a potent, selective and orally bioavailable TRPV1 antagonist with pKi of 7.6 (inhibition of capsaicin-mediated activation of hTRPV1 receptor).
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg (Free Sample) | $18 | In stock | |
| 10 mg | $128 | In stock | |
| 25 mg | $198 | In stock | |
| 50 mg | $328 | In stock | |
| 100 mg | Get quote |
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SB-705498 (SB705498) is a potent, selective and orally bioavailable TRPV1 antagonist with pKi of 7.6 (inhibition of capsaicin-mediated activation of hTRPV1 receptor).
SB-705498 causes rapid and reversible inhibition of the capsaicin (IC50=3 nM), acid (pH 5.3), or heat (50 degrees C; IC50=6 nM)-mediated activation of human TRPV1 (at -70 mV).
| M.Wt | 429.2343 | |
| Formula | C17H16BrF3N4O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
Urea, N-(2-bromophenyl)-N'-[(3R)-1-[5-(trifluoromethyl)-2-pyridinyl]-3-pyrrolidinyl]- |
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1. Rami HK, et al. Bioorg Med Chem Lett. 2006 Jun 15;16(12):3287-91.
2. Gunthorpe MJ, et al. J Pharmacol Exp Ther. 2007 Jun;321(3):1183-92.
3. Chizh BA, et al. Pain. 2007 Nov;132(1-2):132-41.
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