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Chemical Structure : SB 216763
CAS No.: 280744-09-4
Catalog No.: PC-42827Not For Human Use, Lab Use Only.
SB 216763 is a potent, selective, ATP competitive and cell permeable inhibitor GSK-3 with Ki of 9 nM (GSK-3α), equally potent for GSK-3β.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 25 mg | $148 | In stock | |
| 50 mg | $218 | In stock | |
| 100 mg | Get quote | ||
| 200 mg | Get quote | ||
| 1 g | Get quote |
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SB 216763 is a potent, selective, ATP competitive and cell permeable inhibitor GSK-3 with Ki of 9 nM (GSK-3α), equally potent for GSK-3β.
SB 216763 displays no significant activity against a panel of 24 other protein kinases.
SB 216763 stimulates glycogen synthesis in human liver cells and induces expression of a beta-catenin-LEF/TCF regulated reporter gene in HEK293 cells, protects both central and peripheral nervous system neurones in culture from death, activates beta-catenin-mediated transcription, and enhances the survival of CLL lymphocytes.
SB 216763 displays therapeutic properties in a mouse model of pulmonary inflammation and fibrosis.
| M.Wt | 371.2168 | |
| Formula | C19H12Cl2N2O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
1H-Pyrrole-2,5-dione, 3-(2,4-dichlorophenyl)-4-(1-methyl-1H-indol-3-yl)- |
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1. Coghlan MP, et al. Chem Biol. 2000 Oct;7(10):793-803.
2. Cross DA, et al. J Neurochem. 2001 Apr;77(1):94-102.
3. Lu D, et al. Proc Natl Acad Sci U S A. 2004 Mar 2;101(9):3118-23.
4. Gurrieri C, et al. J Pharmacol Exp Ther. 2010 Mar;332(3):785-94.
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