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SBC110736

Chemical Structure : SBC110736

CAS No.: 1629166-02-4

SBC110736 (SBC-110736)

Catalog No.: PC-20907Not For Human Use, Lab Use Only.

SBC110736 is a small molecule inhibitor of proprotein convertase subtilisin kexin type 9 (PCSK9), reduces the release of dsDNA from UVB-induced keratinocytes.

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Biological Activity

SBC110736 is a small molecule inhibitor of proprotein convertase subtilisin kexin type 9 (PCSK9), reduces the release of dsDNA from UVB-induced keratinocytes.
SBC110736 inhibits UVB-induced activation of the cGAS-STING pathway in macrophages.

Physicochemical Properties

M.Wt 413.52
Formula C26H27N3O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

CC(NC1=CC=C(C(N2C(C3=CC=CC=C3)CN(C4=CC=C(C)C=C4)CC2)=O)C=C1)=O

References

1. Chao Luan, et al. J Biol Chem. 2023 Jul;299(7):104895.

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