SBLR876 | RAGE inhibitor | Probechem Biochemicals

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Chemical Structure : SBLR876

SBLR876 (SBLR-876)

Catalog No.: PC-26372Not For Human Use, Lab Use Only.

SBLR876 is a potent RAGE inhibitor, inhibits AGE-RAGE binding with an IC50 of 282.2 nM, blocks downstream NF-κB signaling.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

SBLR876 is a potent RAGE inhibitor, inhibits AGE-RAGE binding with an IC50 of 282.2 nM, blocks downstream NF-κB signaling.
SBLR876 mitigates AGE-BSA–induced oxidative stress and cytotoxicity in HK-2 cells.
SBLR876 attenuates AGE-induced proinflammatory cytokine release in HK-2 cells.
SBLR876 suppresses AGE-induced NF-κB activation in HK-2 cells.
SBLR876 suppresses AGE-induced NF-κB p65 phosphorylation and nuclear translocation in HK-2 cells.

Physicochemical Properties

M.Wt	561.68
Formula	C36H35NO5
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	3-([1,1'-biphenyl]-4-yl)-6-(3-((4aR,8aR)-4a-hydroxyoctahydroisoquinolin-2(1H)-yl)-3-oxopropyl)-5-methyl-7H-furo[3,2-g]chromen-7-one

References

1. Mohammad Al Shahrani M, et al. Biochem Biophys Res Commun. 2026 Mar 5;811:153540.

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SBLR876 (SBLR-876)

Biological Activity

Physicochemical Properties

References

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