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Chemical Structure : SC-68448
Catalog No.: PC-35693Not For Human Use, Lab Use Only.
SC-68448 (SC68448) is a potent, selective peptidomimetic antagonist of the integrin αvβ3 with IC50 of 1 nM, 100-fold selectivity over αIIbβ3.
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SC-68448 (SC68448) is a potent, selective peptidomimetic antagonist of the integrin αvβ3 with IC50 of 1 nM, 100-fold selectivity over αIIbβ3.
SC-68448 inhibits alpha(v)beta3-mediated endothelial cell proliferation in a dose-dependent manner but did not inhibit tumor cell proliferation in cell-based assays; inhibits angiogenesis in vivo in a basic fibroblast growth factor-induced rat corneal neovascularization model.
| M.Wt | 452.292 | |
| Formula | C19H19Cl2N5O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Carron CP, et al. Cancer Res. 1998 May 1;58(9):1930-5.
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