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Chemical Structure : SC144
CAS No.: 895158-95-9
Catalog No.: PC-20420Not For Human Use, Lab Use Only.
SC144 (SC-144) is the first-in-class orally active small-molecule gp130 inhibitor with a broad-spectrum anticancer activity.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 25 mg | $198 | In stock | |
| 100 mg | $498 | In stock | |
| 200 mg | $758 | In stock | |
| 1 g | Get quote |
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SC144 (SC-144) is the first-in-class orally active small-molecule gp130 inhibitor with a broad-spectrum anticancer activity.
SC144 (20 uM) inhibits phosphorylation of STAT1, STAT3, and Akt induced by leukemia inhibitory factor (LIF) and IL-6, but not IFN-γ, in OVCAR-8 ovarian cancer cells.
SC144 binds gp130, induces gp130 phosphorylation (S782) and deglycosylation, abrogates Stat3 phosphorylation and nuclear translocation, and further inhibits the expression of downstream target genes.
SC144 induces cell cycle arrest at the G0/G1 phase in MDA-MB-435 breast and HT-29 colorectal cancer cells and inhibits proliferation of 14 cancer cell lines, including prostate, ovarian, lung, breast, and colorectal cancer cells (IC50=0.4-4 uM).
SC144 reduces tumor growth in OVCAR-8 and MDA-MB-435 mouse xenograft models.
| M.Wt | 322.30 | |
| Formula | C16H11FN6O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
2-Pyrazinecarboxylic acid 2-(7-fluoropyrrolo[1,2-a]quinoxalin-4-yl)hydrazide |
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1. Grande F, et al. Mini Rev Med Chem. 2016;16(8):644-50.
2. Xu S, et al. Mol Cancer Ther. 2013 Jun;12(6):937-49.
3. Plasencia C, et al. Cancer Biol Ther. 2009 Mar;8(5):458-65.
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