Welcome to Shanghai Probechem Biochemicals Co Ltd !Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : SC99
CAS No.: 882290-02-0
Catalog No.: PC-61476Not For Human Use, Lab Use Only.
SC99 is a novel selective STAT3 inhibitor that inhibits JAK2-STAT3 activation but has no effects on other transcription factors such as NF-κB, and kinases such as AKT, ERK, and c-Src.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $148 | In stock | |
| 10 mg | $218 | In stock | |
| 25 mg | $378 | In stock | |
| 50 mg | $568 | In stock | |
| 100 mg | Get quote |
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
SC99 is a novel selective STAT3 inhibitor that inhibits JAK2-STAT3 activation but has no effects on other transcription factors such as NF-κB, and kinases such as AKT, ERK, and c-Src.
SC99 inhibits STAT3 phosphorylation, dimerization and nuclear translocation, downregulates STAT3-modulated gene expression and induces MM cell apoptosis.
SC99 delays tumor growth in MM xenograft models (30mg/kg); orally active.
| M.Wt | 336.147 | |
| Formula | C15H8Cl2FN3O | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
(E)-N-(3-chloro-4-fluorophenyl)-2-(4-chlorophenyl)-2-oxoacetohydrazonoyl cyanide |
|
1. Zhang Z, et al. Oncotarget. 2016 Feb 23;7(8):9296-308.
2. Xu Z, et al. Acta Pharmacol Sin. 2017 May;38(5):651-659.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
