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Chemical Structure : SCH-28080
Catalog No.: PC-62890Not For Human Use, Lab Use Only.
SCH-28080 is a potent, orally active, reversible inhibitor of gastric H+,K+-ATPase with IC50 of 20 nM.
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SCH-28080 is a potent, orally active, reversible inhibitor of gastric H+,K+-ATPase with IC50 of 20 nM; competitively inhibits the K+-stimulated hydrolysis of ATP catalyzed by the H+,K+-ATPase with Ki of 0.12 uM; inhibits gastric ulcers provoked by aspirin, aspirin+ acid, indomethacin and stress (cold-restraint) in rats (1-30 mg/kg p.o.), shows gastric antisecretory and cytoprotective activities.
| M.Wt | 277.33 | |
| Formula | C17H15N3O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Vagin O, et al. Biochemistry. 2002 Oct 22;41(42):12755-62.
2. Long JF, et al. J Pharmacol Exp Ther. 1983 Jul;226(1):114-20.
3. Scott CK, et al. Biochem Pharmacol. 1987 Jan 1;36(1):97-104.
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