Welcome to Shanghai Probechem Biochemicals Co Ltd !Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : SCH-546738
CAS No.: 906805-42-3
Catalog No.: PC-42073Not For Human Use, Lab Use Only.
SCH-546738 (SCH546738) is a potent, selective and non-competitive CXCR3 antagonist with binding Ki of 0.4 nM for human CXCR3.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $258 | In stock | |
| 10 mg | $398 | In stock | |
| 25 mg | Get quote | ||
| 100 mg | Get quote |
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
SCH-546738 (SCH546738) is a potent, selective and non-competitive CXCR3 antagonist with binding Ki of 0.4 nM for human CXCR3.
SCH-546738 displaces radiolabeled CXCL10 and CXCL11 from human CXCR3 with IC50 of 0.8-2 nM.
SCH-546738 potently and specifically inhibits CXCR3-mediated chemotaxis in human activated T cells with IC90 of 10 nM.
SCH-546738 attenuates the disease development in mouse collagen-induced arthritis model.
| M.Wt | 492.4445 | |
| Formula | C23H31Cl2N7O | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
DMSO: 4.5 mg/mL (Need ultrasonic) |
|
| Chemical Name/SMILES |
2-Pyrazinecarboxamide, 3-amino-6-chloro-5-[(3S)-4-[1-[(4-chlorophenyl)methyl]-4-piperidinyl]-3-ethyl-1-piperazinyl]- |
|
1. Jenh CH, et al. BMC Immunol. 2012 Jan 10;13:2.
2. Kim SH, et al. Bioorg Med Chem Lett. 2011 Dec 1;21(23):6982-6. (Compound 8a)
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
