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Chemical Structure : SCH-563705
Catalog No.: PC-42055Not For Human Use, Lab Use Only.
SCH-563705 is a potent, orally bioavailable dual CXCR2/CXCR1 receptor antagonist with IC50 of 1.3 nM and 7.3 nM, respectively.
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SCH-563705 is a potent, orally bioavailable dual CXCR2/CXCR1 receptor antagonist with IC50 of 1.3 nM and 7.3 nM, respectively.
SCH-563705 demonstrates potent inhibition against both Gro-alpha and IL-8 induced hPMN migration (Chemotaxis: CXCR2 IC50=0.5 nM, CXCR1 IC50=37 nM).
SCH-563705 dose-dependently decreases paw thickness and clearly reduces inflammation, and bone and cartilage degradation in a mouse model of arthritis.
| M.Wt | 425.4776 | |
| Formula | C23H27N3O5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥30mg/mL |
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1. Chao J, et al. Bioorg Med Chem Lett. 2007 Jul 1;17(13):3778-83.
2. Min SH, et al. Biochem Biophys Res Commun. 2010 Jan 1;391(1):1080-6.
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