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Chemical Structure : SCH 412348
Catalog No.: PC-63020Not For Human Use, Lab Use Only.
SCH 412348 is a potent and highly selective A2A receptor competitive antagonist with Ki of 0.6 nM.
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SCH 412348 is a potent and highly selective A2A receptor competitive antagonist with Ki of 0.6 nM.
SCH 412348 has >1000-fold selectivity over all other adenosine receptors.
SCH 412348 attenuates hypolocomotion induced by the A2AR agonist CGS-21680.
SCH 412348 exhibits antidepressant-like profiles in models of behavioral despair.
| M.Wt | 465.469 | |
| Formula | C22H21F2N9O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Neustadt BR, et al. Bioorg Med Chem Lett. 2009 Feb 1;19(3):967-71.
2. Smith KM, et al. Eur J Pharmacol. 2014 Apr 5;728:31-8.
3. Grauer SM, et al. Psychopharmacology (Berl). 2014 Apr;231(7):1325-37.
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