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Chemical Structure : SCIO-469
CAS No.: 309913-83-5
Catalog No.: PC-42566Not For Human Use, Lab Use Only.
Talmapimod (SCIO469) is a potent, selective p38α MAPK inhibitor with IC50 of 9 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $128 | In stock | |
| 10 mg | $198 | In stock | |
| 25 mg | $298 | In stock | |
| 50 mg | $458 | In stock | |
| 100 mg | Get quote |
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Talmapimod (SCIO469) is a potent, selective p38α MAPK inhibitor with IC50 of 9 nM.
Talmapimod (SCIO469) displays 10-fold selectivity for p38α over p38β, >2,000-fold selectivity over a panel of 20 other kinases, including other MAP kinases.
Talmapimod (SCIO469) decreases apoptosis in MDS CD34+ progenitors and leads to dose-dependant increases in erythroid and myeloid colony formation.
Talmapimod (SCIO469) enhances the ability of MG132 and bortezomib to induce the apoptosis of MM cells, and inhibits tumor growth in vivo.
| M.Wt | 513.0035 | |
| Formula | C27H30ClFN4O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
1H-Indole-3-acetamide, 6-chloro-5-[[(2R,5S)-4-[(4-fluorophenyl)methyl]-2,5-dimethyl-1-piperazinyl]carbonyl]-N,N,1-trimethyl-α-oxo- |
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1. Navas TA, et al. Leukemia. 2006 Jun;20(6):1017-27.
2. Navas TA, et al. Blood. 2006 Dec 15;108(13):4170-7.
3. Hideshima T, et al. Oncogene. 2004 Nov 18;23(54):8766-76.
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