SCM-08

Chemical Structure : SCM-08

Catalog No.: PC-24397Not For Human Use, Lab Use Only.

SCM-08 is a potent, selective, non-suicide CYP3A4 inhibitor with IC50 of 0.43 uM in P450-Glo inhibition assays, 47-fold selecitve over CYP3A5.

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Biological Activity

SCM-08 is a potent, selective, non-suicide CYP3A4 inhibitor with IC50 of 0.43 uM in P450-Glo inhibition assays, 47-fold selecitve over CYP3A5.
SCM-08 does not inhibit both CYP1A2 and CYP2C19, as well as any of the major human CYPs, including CYP3A7 in the CYP3A subfamily.
SCM-08 remains selective for CYP3A4 in cell-based assays and is not cytotoxic up to 60 µM.

Physicochemical Properties

M.Wt	309.29
Formula	C15H14F3N3O
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(2-(1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl)cyclobutanecarboxamide

References

1. Jingheng Wang, et al. Nat Commun. 2025 Apr 10;16(1):3423.

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SCM-08

Biological Activity

Physicochemical Properties

References

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