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Chemical Structure : SD-1029
Catalog No.: PC-61666Not For Human Use, Lab Use Only.
SD-1029 (NSC 371488) is a potent inhibitor of Stat3 activation, suppresses EGFP-Stat3 nuclear translocation at 10 uM in both BHK-21 and U2-OS cells.
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SD-1029 (NSC 371488) is a potent inhibitor of Stat3 activation, suppresses EGFP-Stat3 nuclear translocation at 10 uM in both BHK-21 and U2-OS cells.
SD-1029 inhibits Stat3-mediated antiapoptotic protein expression (Bcl-XL, MCL-1, and survivin), and suppresses phosphotyrosine levels of JAK2.
SD-1029 inhibits IL-6 or oncostatin-induced Stat3 nuclear translocation at micromolar range, enhances apoptosis induced by paclitaxel in human cancer cells.
| M.Wt | 639.3 | |
| Formula | C25H30Cl2N2O3 • 2HBr | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Duan Z, et al. Clin Cancer Res. 2006 Nov 15;12(22):6844-52.
2. Yang C, et al. Mol Cancer Ther. 2009 Sep;8(9):2597-605.
3. Che Mat NF, et al. J Interferon Cytokine Res. 2011 Apr;31(4):363-71.
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