SD2-2305

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Chemical Structure : SD2-2305

Catalog No.: PC-27261Not For Human Use, Lab Use Only.

SD2-2305 is a potent dopamine receptor D2 (DRD2) antagonist, induces caspase-dependent apoptosis in CRC cells.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

SD2-2305 is a potent dopamine receptor D2 (DRD2) antagonist, induces caspase-dependent apoptosis in CRC cells.
SD2-2305 (0-15 uM) induces apoptosis in human CRC cells HCT116 and HT-29.
SD2-2305 (0-15 uM) arrests the cell cycle at the G1 phase and decreases the levels of cellular cyclin/CDK proteins.
SD2-2305-induced apoptosis is not associated with marked changes in JAK/STAT or PI3K/Akt signaling.
SD2-2305 downregulates HER2 protein levels while upregulating TGF-β receptor 1 in CRC cells.

Physicochemical Properties

M.Wt	486.40
Formula	C24H25Cl2N5O2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	5-chloro-N-(3-(4-(5-chloro-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)piperidin-1-yl)propyl)-1H-indole-2-carboxamide

References

1. Kim NH, et al. Biomol Ther (Seoul). 2026 Jul 1;34(4):901-909.

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SD2-2305

Biological Activity

Physicochemical Properties

References

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