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Chemical Structure : SEA 0400
CAS No.: 223104-29-8
Catalog No.: PC-73275Not For Human Use, Lab Use Only.
SEA0400 is a potent and selective Na(+)/Ca(2+) exchanger (NCX) inhibitor, inhibits Na+-dependent Ca2+ uptake in cultured neurons, astrocytes, and microglia with IC50 of 5-33 nM.
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|---|---|---|---|
| 10 mg | $198 | In stock | |
| 25 mg | $348 | In stock | |
| 100 mg | $878 | In stock | |
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SEA0400 is a potent and selective Na(+)/Ca(2+) exchanger (NCX) inhibitor, inhibits Na+-dependent Ca2+ uptake in cultured neurons, astrocytes, and microglia with IC50 of 5-33 nM.
SEA0400 is more potent than KB-R7943.
SEA0400 is NCX selective, does not affect the activities of the Na+/H+ exchanger, Na+,K+-ATPase, Ca2+-ATPase.
SEA0400 preferentially inhibits (45)Ca(2+) uptake by NCX1 compared with inhibitions by NCX2, NCX3, and NCKX2.
EA0400 also selectively blocked outward exchange currents from NCX1 transfectants.
SEA0400 protected against hypoxia/reoxygenation-induced cell damage in tubular cells expressing wild-type NCX1.
SEA0400 attenuated dose- dependently paradoxical Ca2+ challenge-induced production of reactive oxygen species, DNA ladder formation, and nuclear condensation in cultured astrocyte.
SEA0400 reduced infarct volumes after a transient middle cerebral artery occlusion in rat cerebral cortex and striatum.
| M.Wt | 371.384 | |
| Formula | C21H19F2NO3 | |
| Appearance | Solid | |
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| Solubility |
10 mM in DMSO |
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1. Takahiro Iwamoto, et al. J Biol Chem. 2004 Feb 27;279(9):7544-53.
2. T Matsuda, et al. J Pharmacol Exp Ther. 2001 Jul;298(1):249-56.
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