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Chemical Structure : SEN 1269
Catalog No.: PC-63233Not For Human Use, Lab Use Only.
SEN1269 is a novel potent Aβ aggregation inhibitor that binds to monomeric Aβ1-42 with Kd of 4.4 uM, protects neuronal cell lines against an Aβ1-42 insult with IC50 of 15 uM.
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SEN1269 is a novel potent Aβ aggregation inhibitor that binds to monomeric Aβ1-42 with Kd of 4.4 uM, protects neuronal cell lines against an Aβ1-42 insult with IC50 of 15 uM; produces a concentration-related blockade of Aβ(1-42) aggregation and protects neuronal cell lines exposed to Aβ(1-42); alleviates deficits in hippocampal LTP induced by Aβ(1-42) and cell-derived Aβ oligomers; reduces Aβ-induced neurotoxicity and shows neuroprotective in behavioural models of memory relevant to Aβ-induced neurodegeneration.
| M.Wt | 322.368 | |
| Formula | C18H18N4O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Scopes DI, et al. Br J Pharmacol. 2012 Sep;167(2):383-92.
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