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Chemical Structure : SERCA2a activator A
CAS No.: 2139330-34-8
Catalog No.: PC-61779Not For Human Use, Lab Use Only.
SERCA2a activator A is a novel sarco/endoplasmic reticulum Ca2+-dependent ATPase 2a (SERCA2a) activator that activates the Ca2+-dependent ATPase activity of cardiac SR vesicles but not that of skeletal muscle SR vesicles that lack of phospholamban (PLN).
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|---|---|---|---|
| 5 mg | $558 | In stock | |
| 10 mg | $898 | In stock | |
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SERCA2a activator A is a novel sarco/endoplasmic reticulum Ca2+-dependent ATPase 2a (SERCA2a) activator that activates the Ca2+-dependent ATPase activity of cardiac SR vesicles but not that of skeletal muscle SR vesicles that lack of phospholamban (PLN).
SERCA2a activator A binds to PLN (Kd=75 uM), attenuates its inhibition of SERCA2a; enhances systolic and diastolic functions in rat hearts.
| M.Wt | 551.661 | |
| Formula | C32H29N3O4S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
5'-benzyl-1'-butyl-N-(naphthalen-2-ylsulfonyl)-6'-oxo-1',6'-dihydro-[2,3'-bipyridine]-4-carboxamide |
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1. Kaneko M, et al. Eur J Pharmacol. 2017 Nov 5;814:1-8.
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