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Chemical Structure : SEW2871
CAS No.: 256414-75-2
Catalog No.: PC-60766Not For Human Use, Lab Use Only.
SEW2871 is a potent, selective S1P1 receptor full agonist with EC50 of 13.8 nM, with no activites at the S1P2-5 receptors.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $158 | In stock | |
| 10 mg | $248 | In stock | |
| 25 mg | $398 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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SEW2871 is a potent, selective S1P1 receptor full agonist with EC50 of 13.8 nM, with no activites at the S1P2-5 receptors.
SEW2871 activates ERK, Akt, and Rac signaling pathways and induced S1P(1) internalization and recycling.
SEW2871 also inhibits transendothelial migration of medullary T cells to lymphatic sinuses.
| M.Wt | 440.4 | |
| Formula | C20H10F6N2OS | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
5-[4-phenyl-5-(trifluoromethyl)-2-thienyl]-3-[3-(trifluoromethyl)phenyl]-1,2,4-oxadiazole |
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1. Jo E, et al. Chem Biol. 2005 Jun;12(6):703-15.
2. Wei SH, et al. Nat Immunol. 2005 Dec;6(12):1228-35.
3. Lien YH, et al. Kidney Int. 2006 May;69(9):1601-8.
4. Whetzel AM, et al. Circ Res. 2006 Sep 29;99(7):731-9.
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