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Chemical Structure : SF1670
CAS No.: 345630-40-2
Catalog No.: PC-49492Not For Human Use, Lab Use Only.
SF1670 (SF 1670) is a highly potent and specific small molecule PTEN inhibitor with IC50 of 2 uM, increases cellular PtdIns(3,4,5)P3 levels, phosphorylation of Akt, and glucose uptake in adipocytes at nanomolar concentrations.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 25 mg | $228 | In stock | |
| 50 mg | $398 | In stock | |
| 100 mg | $598 | In stock | |
| 250 mg | Get quote | ||
| 1 g | Get quote |
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SF1670 (SF 1670) is a highly potent and specific small molecule PTEN inhibitor with IC50 of 2 uM, increases cellular PtdIns(3,4,5)P3 levels, phosphorylation of Akt, and glucose uptake in adipocytes at nanomolar concentrations.
SF1670 (500 nM) enhances fMLP-induced PtdIns(3,4,5)P3 signaling in both human and mouse neutrophils.
SF1670 increases chemoattractant-elicited superoxide production in both human and mouse neutrophils, augments fMLP-induced polarization and chemotaxis.
SF1670 enhances the recruitment of transfused neutrophils to the inflamed peritoneal cavity, as well as the bactericidal capability of the host.
| M.Wt | 307.34 | |
| Formula | C19H17NO3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
N-(9,10-dioxo-9,10-dihydrophenanthren-2-yl)pivalamide |
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1. Li Y, et al. Blood. 2011 Jun 16;117(24):6702-13.
2. Rosivatz E, et al. ACS Chem Biol. 2006;1(12):780–790.
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