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Chemical Structure : SGC-CLK-1
Catalog No.: PC-21431Not For Human Use, Lab Use Only.
SGC-CLK-1 (CAF-170) is a potent and selective inhibitor of Cdc2-Like kinases CLK1, 2 and 4 with binding IC50 values of 13 nM, 4 nM, and 46 nM, resepctively.
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SGC-CLK-1 (CAF-170) is a potent and selective inhibitor of Cdc2-Like kinases CLK1, 2 and 4 with binding IC50 values of 13 nM, 4 nM, and 46 nM, resepctively.
SGC-CLK-1 (CAF-170) poorly inhibits CLK3 with IC50 of 363 nM.
SGC-CLK-1 (CAF-170) binds to CLK1, CLK2, and CLK4 with cellular IC50 values below 200 nM, with the CLK2 cellular affinity the best, at 58 nM.
SGC-CLK-1 (CAF-170) is active against multiple cancer types, not only reduces serine arginine rich (SR) protein phosphorylation, but also alters SR protein and CLK2 subcellular localization in a reversible way.
| M.Wt | 416.36 | |
| Formula | C19H15F3N6O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Tiek D, et al. Curr Res Chem Biol. 2023;3:100045.
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