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SGD-1882

Chemical Structure : SGD-1882

CAS No.: 1222490-34-7

SGD-1882 (PBD dimer;Pyrrolobenzodiazepine dimer)

Catalog No.: PC-60141Not For Human Use, Lab Use Only.

PBD dimer;Pyrrolobenzodiazepine dimer novel potent DNA-intercalating payload dimer (PBD dimer) payload for antibody-drug conjugates (ADCs).

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    SGD-1882 (PBD dimer, Pyrrolobenzodiazepine dimer) is a novel potent DNA-intercalating payload dimer (PBD dimer) payload for antibody-drug conjugates (ADCs).

    Physicochemical Properties

    M.Wt 725.802
    Formula C42H39N5O7
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    (S)-2-(4-aminophenyl)-7-methoxy-8-(3-(((S)-7-methoxy-2-(4-methoxyphenyl)-5-oxo-5,11a-dihydro-1H-benzo[e]pyrrolo[1,2-a][1,4]diazepin-8-yl)oxy)propoxy)-1,11a-dihydro-5H-benzo[e]pyrrolo[1,2-a][1,4]diazepin-5-one

    References

    1. Sean W. Smith, et al. ACS Med. Chem. Lett. DOI: 10.1021/acsmedchemlett.7b00436

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