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SHP-099

Chemical Structure SHP-099

CAS No.: 1801747-42-1

SHP-099 (SHP099)

Catalog No.: PC-42128Not For Human Use, Lab Use Only.

A potent, selective, allosteric and orally bioavailable protein tyrosine phosphatase SHP2 inhibitor with IC50 of 71 nM.

Packing Price Stock Quantity
5 mg $72 In stock
10 mg $120 In stock
50 mg $360 In stock
100 mg $512 In stock
500 mg Get quote

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

A potent, selective, allosteric and orally bioavailable protein tyrosine phosphatase SHP2 inhibitor with IC50 of 71 nM; exhibits excellent phosphatase selectivity profiling over a panel of 21 human phosphatases (including SHP1) and a panel of 66 serine-threonine and tyrosine kinase; inhibits p-ERK with an IC50 of ~0.25 uM in SHP2- dependent MDA-MB-468 and KYSE520 cells, suppresses RAS–ERK signalling to inhibit the proliferation of receptor-tyrosine-kinase-driven human cancer cells in vitro and is efficacious in mouse tumour xenograft models.

Physicochemical Properties

M.Wt 352.2616
Formula C16H19Cl2N5
CAS No. 1801747-42-1
Storage
Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 1 Month
Shipping
Solubility

DMSO: 6.4 mg/mL (Need ultrasonic)

Chemical Name

2-Pyrazinamine, 6-(4-amino-4-methyl-1-piperidinyl)-3-(2,3-dichlorophenyl)-

Clinical Information

References

1. Garcia Fortanet J, et al. J Med Chem. 2016 Sep 8;59(17):7773-82.

2. Chen YN, et al. Nature. 2016 Jul 7;535(7610):148-52.

3. Flemming A. Nat Rev Drug Discov. 2016 Jul 29;15(8):530-1.

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