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Chemical Structure : SI-113
CAS No.: 1392816-46-4
Catalog No.: PC-70209Not For Human Use, Lab Use Only.
SI-113 (SI 113) is a potent, specific inhibitor of the SGK1 kinase activity, induces autophagy, apoptosis and ER stress in cancer cells.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 25 mg | $498 | In stock | |
| 100 mg | $998 | In stock | |
| 250 mg | Get quote | ||
| 1 g | Get quote |
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SI-113 (SI 113) is a potent, specific inhibitor of the SGK1 kinase activity, induces autophagy, apoptosis and ER stress in cancer cells.
SI-113 blocks insulin-dependent phosphorylation of the Sgk1 substrate Mdm2, and induces necrosis and apoptosis in RKO cells.
SI-113 potentiates the effects of paclitaxel on cell viability; active in vivo.
| M.Wt | 400.486 | |
| Formula | C23H24N6O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
2-((4-(phenethylamino)-1-styryl-1H-pyrazolo[3,4-d]pyrimidin-6-yl)amino)ethan-1-ol |
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1. D'Antona L, et al. Cell Physiol Biochem. 2015;35(5):2006-18.
2. Talarico C, et al. Oncotarget. 2015 Nov 10;6(35):37511-25.
3. Talarico C, et al. Oncotarget. 2016 Mar 29;7(13):15868-84.
4. Radi M, et al. J Med Chem. 2011 Apr 28;54(8):2610-26.
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