Welcome to Shanghai Probechem Biochemicals Co Ltd !Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : SIJ1772
Catalog No.: PC-21798Not For Human Use, Lab Use Only.
SIJ1772 is a potent mutated RAS (mtRAS)-signaling pathway blocker/inhibitor with IC50 of 77 and 96 nM for Ba/F3-NRAS-G12D and Ba/F3-NRAS-G12V, respectively.
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
SIJ1772 is a potent mutated RAS (mtRAS)-signaling pathway blocker/inhibitor with IC50 of 77 and 96 nM for Ba/F3-NRAS-G12D and Ba/F3-NRAS-G12V, respectively.
SIJ1772 attenuates phosphorylation of RAS downstream molecules (AKT and MEK) and induce apoptosis and G0/G1 cell cycle arrest on cancer cells with mtRAS.
SIJ1772 suppresses the migration, invasion, and colony formation of cancer cells harboring mtRAS.
| M.Wt | 683.71 | |
| Formula | C31H32F3N9O4S | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
1. Kim N, et al. Front Oncol. 2021 Dec 9;11:768022.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
