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Chemical Structure : SIJ1795
Catalog No.: PC-21797Not For Human Use, Lab Use Only.
SIJ1795 is a potent mutated RAS (mtRAS)-signaling pathway blocker/inhibitor with IC50 of 82 and 75 nM for Ba/F3-NRAS-G12D and Ba/F3-NRAS-G12V, respectively.
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SIJ1795 is a potent mutated RAS (mtRAS)-signaling pathway blocker/inhibitor with IC50 of 82 and 75 nM for Ba/F3-NRAS-G12D and Ba/F3-NRAS-G12V, respectively.
SIJ1795 attenuates phosphorylation of RAS downstream molecules (AKT and MEK) and induce apoptosis and G0/G1 cell cycle arrest on cancer cells with mtRAS.
SIJ1795 suppresses the migration, invasion, and colony formation of cancer cells harboring mtRAS.
| M.Wt | 644.70 | |
| Formula | C34H35F3N8O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Kim N, et al. Front Oncol. 2021 Dec 9;11:768022.
2. Cho H, et al. J Med Chem (2018) 61:8353–73.
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